How it works.

Follow the below steps to get ready to make your first dosing request!

  1. Register to create an account.

    Nowadays, keeping track of all your login details for various websites is quite a task. That’s why the OPTI-CLOT web portal uses SURFconext. This allows you to log in with the account you received from your healthcare institution, so you don’t need to create a new account for the portal!

    Before you can use the OPTI-CLOT portal, you will need to register. This way, we can ensure that only appropriate users have access to the platform. The OPTI-CLOT web portal is intended for healthcare providers involved in the care of patients with bleeding disorders. If your center is not yet connected to the OPTI-CLOT portal, your registration may take longer. In such cases, we will inform you before hand and a responsible person for the use of the OPTI-CLOT portal may be appointed within your center.

  2. Safely send a request for dosing advice.

    Given that the OPTI-CLOT portal works with sensitive data, the application has undergone thorough security checks. All data is stored in compliance with high-quality standards (NEN 7510 & ISO 27001). Only the pharmacologists at AMC have access to your patient's data. All changes to the data are tracked, so any errors can always be corrected.

    In today's world, the administrative burden on healthcare providers is high. Therefore, our goal is to support the user with data entry as much as possible. The OPTI-CLOT portal uses a single form for entering patient data. This form is dynamically adjusted so that you only need to enter the relevant information for your patient.

    Our goal is to provide a one-stop overview of all data related to the care of patients with bleeding disorders. This makes it easier to keep track of things. Do you have suggestions for additions or adjustments? Don't hesitate to contact us!

  3. Receive dosing advice based on the individual pharmacokinetic profile of your patient.

    To give advice regarding the optimal treatment for your patient, we use models based on population pharmacokinetics. These models use data from a large population of patients to make predictions about your specific patient. Unfortunately, this prediction is not (yet) perfect. Fortunately, the model also quantifies the error of predictions, and the addition of blood measurement of the drug can reduce this uncertainty. This is not mandatory in the OPTI-CLOT portal, but it is recommended to improve the accuracy of the dosing advice.

    When you submit a request in the OPTI-CLOT portal, it is personally handled by our OPTI-CLOT pharmacologists. They work with your patient’s data to provide personalized advice tailored to the situation of your patient. Therefore, there is always a human element involved in the dosing advice.

  4. Personalise the dosing advice.

    The given dosing advice is fully interactive and can be edited in the portal. This allows you to compare different treatments and select the optimal one for your patient.

    At the current moment, the dosing advice from the OPTI-CLOT portal are primarily focussed on achieving a specific, pre-defined target concentration. In the future, it will also be possible to support treatment selection based on your patient's bleeding risk. Given the high variation in bleeding frequency among patients receiving the same treatment, this will allow us to further tailor the treatment to your patient. This can also help support your intuition about your patient's bleeding phenotype.

  5. Keep all your requests and treatment advice in one clear overview.

    After logging into the OPTI-CLOT web portal, you will see an overview of all the requests you have made to the OPTI-CLOT portal. You can sort and filter the results to find the right request. Additionally, each request is linked to a patient (based on a pseudo ID). This allows you to track your patient’s data, including changing pharmacokinetics, over time.

    One of the goals of the OPTI-CLOT web portal is to standardize the tracking and presentation of pharmacokinetic data across healthcare centers. These outcomes can be complex, which can make it challenging for healthcare providers to draw conclusions from them. Through improved education, we hope that this type of information can add value to the treatment of patients with bleeding disorders.